Protein Misfolding Diseases

Informationen zum Autor MARINA RAMIREZ-ALVARADO is an Assistant professor of Biochemistry and Molecular Biology at the Mayo Clinic. Despite being a young investigator, she is already a world leader in the study of molecular determinants of light chain amyloidosis, a reare misfolding disease.JEFFERY W. KELLY is a Professor of Chemistry and Molecular and Experimental Medicine at the Scripps Research Institute. He is one of the leading authorities in the field of protein misfolding, with over 250 publications to his credit.CHRISTOPHER M. DOBSON is a Professor in the Department of Chemistry at the University of Cambridge. Dr. Dobson is a leading researcher studying the structure and biochemical bases of protein misfolding diseases and has over 500 publications. Klappentext An in-depth look at new discoveries in protein misfolding disease researchProtein misfolding/aggregation diseases are a medical puzzle that has baffled researchers for many years. These diseases are characterized by the presence of protein deposits, or amyloid fibrils, which gather in the intracellular and/or extracellular spaces in a variety of tissues. Unchecked, the process of amyloidogenesis leads to proteotoxicity, cell loss, and eventually organ dysfunction, and causes such well-known and devastating diseases as Alzheimer's, Parkinson's, and Mad Cow.Employing a diversity of research approaches, including chemical and biophysical, cellular, and animal models, the authors investigate various amyloid diseases and outline progress made in understanding them in this important book. Included are novel strategies to combat a wide variety of degenerative diseases. With a systematic overview, Protein Misfolding Diseases:* Emphasizes therapeutics in an amyloid disease context, which helps bridge the gap between basic science and pharmaceutical applications to protein misfolding diseases* Provides a comprehensive survey of many of the topics surrounding the universal biological aspects of protein misfolding* Includes a Foreword by R. John Ellis, International Gairdner Award Winner 2004* Is coedited by Jeffery W. Kelly and Christopher M. Dobson, leaders in the field of protein biochemistryProtein Misfolding Diseases uses the latest medical data from expert scientists and protein misfolding clinicians to launch a multi-targeted assault on the process of amyloid fibril formation. Fresh insight into the etiology of these maladies helps researchers gain a thorough understanding of the bases of these diseases and offers guidance in designing therapeutic strategies to build on promising new findings--and bring hope one step closer to reality. Zusammenfassung An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease. Inhaltsverzeichnis CONTRIBUTORS.FOREWORD (R. John Ellis).PREFACE.ACKNOWLEDGMENTS.INTRODUCTION TO THE WILEY SERIES ON PROTEIN AND PEPTIDE SCIENCE (Vladimir N. Uversky).PART I PRINCIPLES OF PROTEIN MISFOLDING.1 Why Proteins Misfold (Silvia Campioni, Elodie Monsellier, and Fabrizio Chiti).2 Endoplasmic Reticulum Stress and Oxidative Stress: Mechanisms and Link to Disease (Jyoti D. Malhotra and Randal J. Kaufman).3 Role of Molecular Chaperones in Protein Folding (Kausik Chakraborty, Florian Georgescauld, Manajit Hayer-Hartl, and F. Ulrich Hartl).4 Kinetic Models for Protein Misfolding and Association (Evan T. Powers and Frank A. Ferrone).5 Toxicity in Amyloid Diseases (Massimo Stefani).6 Autophagy: An Al...

Autorentext
MARINA RAMIREZ-ALVARADO is an Assistant professor of Biochemistry and Molecular Biology at the Mayo Clinic. Despite being a young investigator, she is already a world leader in the study of molecular determinants of light chain amyloidosis, a reare misfolding disease. JEFFERY W. KELLY is a Professor of Chemistry and Molecular and Experimental Medicine at the Scripps Research Institute. He is one of the leading authorities in the field of protein misfolding, with over 250 publications to his credit. CHRISTOPHER M. DOBSON is a Professor in the Department of Chemistry at the University of Cambridge. Dr. Dobson is a leading researcher studying the structure and biochemical bases of protein misfolding diseases and has over 500 publications.

Klappentext
An in-depth look at new discoveries in protein misfolding disease research Protein misfolding/aggregation diseases are a medical puzzle that has baffled researchers for many years. These diseases are characterized by the presence of protein deposits, or amyloid fibrils, which gather in the intracellular and/or extracellular spaces in a variety of tissues. Unchecked, the process of amyloidogenesis leads to proteotoxicity, cell loss, and eventually organ dysfunction, and causes such well-known and devastating diseases as Alzheimer's, Parkinson's, and Mad Cow. Employing a diversity of research approaches, including chemical and biophysical, cellular, and animal models, the authors investigate various amyloid diseases and outline progress made in understanding them in this important book. Included are novel strategies to combat a wide variety of degenerative diseases. With a systematic overview, Protein Misfolding Diseases: * Emphasizes therapeutics in an amyloid disease context, which helps bridge the gap between basic science and pharmaceutical applications to protein misfolding diseases * Provides a comprehensive survey of many of the topics surrounding the universal biological aspects of protein misfolding * Includes a Foreword by R. John Ellis, International Gairdner Award Winner 2004 * Is coedited by Jeffery W. Kelly and Christopher M. Dobson, leaders in the field of protein biochemistry Protein Misfolding Diseases uses the latest medical data from expert scientists and protein misfolding clinicians to launch a multi-targeted assault on the process of amyloid fibril formation. Fresh insight into the etiology of these maladies helps researchers gain a thorough understanding of the bases of these diseases and offers guidance in designing therapeutic strategies to build on promising new findings--and bring hope one step closer to reality.

Zusammenfassung
An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.

Inhalt
CONTRIBUTORS. FOREWORD (R. John Ellis). PREFACE. ACKNOWLEDGMENTS. INTRODUCTION TO THE WILEY SERIES ON PROTEIN AND PEPTIDE SCIENCE (Vladimir N. Uversky). PART I PRINCIPLES OF PROTEIN MISFOLDING. 1 Why Proteins Misfold (Silvia Campioni, Elodie Monsellier, and Fabrizio Chiti). 2 Endoplasmic Reticulum Stress and Oxidative Stress: Mechanisms and Link to Disease (Jyoti D. Malhotra and Randal J. Kaufman). 3 Role of Molecular Chaperones in Protein Folding (Kausik Chakraborty, Florian Georgescauld, Manajit Hayer-Hartl, and F. Ulrich Hartl). 4 Kinetic Models for Protein Misfolding and Association (Evan T. Powers and Frank A. Ferrone). 5 Toxicity in Amyloid Diseases (Massimo Stefani). 6 Autophagy: An Alternative Degradation Mechanism for Misfolded Proteins (Maria Kon an…

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