Molecular Biology of B Cells

Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.Covers signaling mechanisms regulating B cell differentiationProvides information on the development of therapeutics using monoclonal antibodies and clinical application of AbContains studies on B cell tumors from various stages of B lymphocytesOffers an integrated view of all aspects of B cells to produce a normal immune response

Inhalt
1. Ig loci: structure and expression regulation 2. The mechanisms of V(D)J recombination 3. Transcriptional regulation of B lymphocyte differentiation 4. B cell transcriptome 5. The role of microRNA in B cell development and function 6. Proliferation and differentiation program of developing B cells 7. Development and function of B cell subsets 8. Evolution of primordial B cell antigen receptor 9. The evolutionary origin of V(D)J diversification 10. Receptor organization on B cells and its signaling 11. Fc and complement responses 12. The dynamic structure of germinal center: generation of high affinity Ab 13. Cell Migration 14. B cell as regulator 15. B cell memory and plasma cell development 16. Roles of lymphotoxin and Baff on B cells 17. The mucosal immune system: host-bacteria interaction and regulation of IgA synthesis 18. Gut microbiota and their regulation 19. Regulation and function of activation-induced cytidine deaminase 20. Molecular mechanism of CSR 21. Molecular mechanism of SHM 22. Aberrant AID expression by pathogen infection 23. Chromosomal translocation and mutations in B cell leukemia and lymphomas 24. B cells producing pathogenic autoantibodies 25. HIV neutralizing Ab 26. Immune deficiency caused by B cell defects 27. IMGT® for immunoglobulin repertoire analysis and antibody humanization 28. Humanized monoclonal Ab production 29. Ab therapy against lymphoma 30. Anti-interleukin-6 receptor antibody therapy against autoimmune inflammatory diseases 31. Ab therapy against chronic inflammatory immune-mediated diseases

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