Neoplastic Diseases of the Blood

Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia- Chronic Leukemias and Related Disorders , Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. Chapters feature an accessible and easy-to-read layout and provide updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. An authoritative and indispensable resource for students, trainees, and clinicians, this fifth edition is sure to distinguish itself as the definitive reference on this topic.

Klappentext
Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia Chronic Leukemias and Related Disorders , Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. Chapters feature an accessible and easy-to-read layout and provide updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. An authoritative and indispensable resource for students, trainees, and clinicians, this fifth edition is sure to distinguish itself as the definitive reference on this topic.

Inhalt
Part I: Chronic Leukemias and Related Disorders

1: A History of the Chronic Leukemias
John M. Goldman and Myrtle Y. Gordon

2: Etiology and Epidemiology of Chronic Myeloid Leukemia
Maren Rohrbacher and Joerg Hasford

3: Pathology of the Chronic Myeloid Leukemias
Barbara J. Bain

4: Molecular Biology and Cytogenetics of Chronic Myeloid Leukemia
Alfonso Quintás Cardama, Hagop Kantarjian, and Jorge Cortes

5: Diagnosis and Treatment of Chronic Myeloid Leukemia
Stephen G. O'Brien and John M. Goldman

6: Etiology and Epidemiology of CLL
Dalemari Crowther-Swanepoel, Daniel Catovsky, and
Richard S. Houlston

7: Histopathology, Morphology, and Immunophenotyping of CLL
Abraham M. Varghese, Andy C. Rawstron, Roger G. Owen, and Peter Hillmen

8: Molecular Biology and Cytogenetics of Chronic Lymphocytic Leukemia
David Oscier, Anne Gardiner, and Jonathan C. Strefford

9: Treatment of Chronic Lymphocytic Leukemia and Related Disorders
Gautam Borthakur and Susan O'Brien

10: Hairy Cell Leukemia
Sejal A. Jhatakia, Darren S. Sigal, and Alan Saven

11: The Pathogenesis, Diagnosis, and Treatment of Polycythemia Vera
Mark A. Dawson and Brian J.P. Huntly

12: Diagnosis and Treatment of Essential Thrombocythemia and Primary Myelofibrosis
John T. Reilly

Part II: Acute Leukemias

13: History of Acute Leukemia
Emil J Freireich

14: The Etiology of Acute LeukemiaJessica N. Nichol, Sarit Assouline, and Wilson H. Miller

15: Epidemiology and Hereditary Aspects of Acute Leukemia
Martha S. Linet, Graca M. Dores, Clara J. Kim, Susan S. Devesa, and Lindsay M. Morton

16: Classification of the Acute Leukemias: Cytochemical and Morphologic Considerations
Nukhet N. Tuzuner and John M. Bennett

17: Immunobiology of Acute LeukemiaElisabeth Paietta

18: Cytogenetics of Acute Leukemia
Nyla A. Heerema and Susana Catalina Raimondi

19: Diagnosis and Treatment of Childhood Acute Lymphoblastic Leukemia
Dario Campana and Ching-Hon Pui

20: Diagnosis and Treatment of Adult Acute Lymphoblastic Leukemia
Nicola Goekbuget and Dieter Hoelzer

21: Diagnosis and Treatment of Childhood Acute Myeloid Leukemia
David A. Sweetser and Howard J. Weinstein

22: Diagnosis and Treatment of Adult Acute Myeloid Leukemia Other Than Acute Promyelocytic Leukemia
Peter H. Wiernik

23: Acute Promyelocytic Leukemia
Peter H. Wiernik, Robert E. Gallagher, and Martin S. Tallman

24: Therapy-Related Acute Myelogenous Leukemia
Gabriela Bernadeta Iwanski, Nils Heinrich Thoennissen, Dorothy J. Park, and H. Phillip Koeffler

25: The Myelodysplastic Syndromes
Kenneth Miller and Igor Rozenvald

Part III: Myeloma and Related Diseases

26: History of Multiple Myeloma
David P. Steensma and Robert A. Kyle

27: Cytokines and Signal Transduction in Multiple Myeloma
Dharminder Chauhan and Kenneth C. Anderson

28: Epidemiology of Multiple Myeloma
Dalsu Baris, Linda Morris Brown, Gabriella Andreotti, and Susan S. Devesa

29: Immunoglobulins and Laboratory Recognition of Monoclonal Proteins
Jerry Katzmann, Robert A. Kyle, John Lust, Melissa Snyder, and Angela Dispenzieri

30: Cytogenetic Abnormalities in MGUS and Myeloma
Rafael Fonseca, P. Leif Bergsagel, and W. Michael Kuehl

31: Molecular Genetics of Myeloma
Brian Van Ness

32: Prognosis and Staging of Multiple Myeloma
Jesús F. San-Miguel, Ramón García-Sanz, and Norma C. Gutiérrez

33: Diagnosis and Treatment of Multiple Myeloma
S.Vincent Rajkumar and Robert A. Kyle

34: Complications and Special Presentations of Plasma Cell Myeloma
Joan Bladé and Laura Rosiñol

35: Waldenström's Macroglobulinemia
Efstathios Kastritis and Meletios A. Dimopoulos

36: Heavy-Chain Disease
Dietlind L. Wahner-Roedler and Robert A. Kyle

37: Diagnosis and Therapy of Immunoglobulin Light Chain Amyloidosis (AL Amyloidosis)
Morie A. Gertz and Robert A. Kyle

38: Monoclonal Gammopathy of Undetermined Significance
Robert A. Kyle and S. Vincent Rajkumar

Part IV: Lymphoma

39: Historical Landm...

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