Pharmacology of Histamine Receptors

Pharmacology of Histamine Receptors presents a summary of the pharmacology of histamine receptors. It discusses the research and developments made in the use of histamine. It addresses the biological actions of the drug in various pathological instances.
Some of the topics covered in the book are the classification of histamine receptors; mepyramine and related histamine antagonists; activity relationships of drugs acting at histamine receptors; chemical structure of histamine; effects of methyl substituents in histamine; enzymes involved in histamine metabolism; and histamine in body fluids. The cellular sources of histamine in tissues and blood are fully covered. The relationship of the mast cell to basophil is discussed in detail. The text describes in depth the urinary excretion of histamine and metabolites. The pathological conditions in man are presented completely. A chapter is devoted to the fundamental properties of adenylate cyclase and its measurement.
The book can provide useful information to pharmacists, doctors, chemists, students, and researchers.

Inhalt
Contents
List of Abbreviations

Foreword

1. Reflections on the Classification of Histamine Receptors

2. Chemistry and Structure-Activity Relationships of Drugs Acting at Histamine Receptors

3. Factors Regulating Availability of Histamine at Tissue Receptors

4. Histamine Receptors and Cyclic Nucleotides

5. Histamine Receptors and Gastric Secretion

6. Actions of Histamine On The Heart and Vasculature

7. Histamine Receptor Mechanisms of The Lung

8. Histamine Receptors in Alimentary and Genito-Urinary Smooth Muscle

9. Histamine Receptors in The Brain and Their Possible Functions

10. Histamine and Immune Responses

11. The Pathophysiological Role of Histamine and Potential Therapeutic Uses of H1 and H2 Antihistamines

Index

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