Herausgeber:
Elsevier Science & Techn.
Erscheinungsdatum:
28.06.2014
Psychoneuroimmunology, Second Edition presents reports on the relationship between the nervous and immune systems.
The book is divided into four sections. The first section details the role of neural structures and neurotransmitter signals in communication with the immune system. It documents the extensive neural connections with organs of the immune system; the dynamics of noradrenergic sympathetic innervation of spleen and thymus; and the evidence for immune signaling of the CNS. Part II elaborates the role of hormones in the modulation of immune functions; the basis for bidirectional communication between the neuroendocrine and immune systems; and the potential physiological implications of these neuroendocrine-immune system interactions. The third part addresses behavioral influences on immune response; the effects of conditioning, stress and social interactions in modulating immune responses; and the behavioral consequences of experimentally altered or genetically determined immunologic states. The final section presents the effects of psychosocial factors on immune responses and the potential impact of behavioral interventions in modulating immunity in healthy human subjects and in patients with AIDS.
Neuroscientists, endocrinologists, and immunologists will find the book interesting.
Inhalt
Contributors
Preface
Part I Neurochemical Links between the Nervous and Immune Systems
Central Neural Circuits Involved in Neural-Immune Interactions
Introduction
Effects of CNS Lesions on the Immune System
CNS Responses to Immunization
Mediators of Immune-Neural Communication
Immunologic Effects on Behavior
Conclusions
References
Innervation of Lymphoid Tissue
Introduction
Bone Marrow
Thymus
Spleen
Lymph Nodes
Other Lymphoid Accumulations
Interpreting Neuroanatomical Data
Summary
References
Ontogeny and Senescence of Noradrenergic Innervation of the Rodent Thymus and Spleen
Introduction
Ontogeny of Sympathetic Neurotransmission in the Thymus
Ontogeny of Sympathetic Neurotransmission in the Spleen
Noradrenergic Innervation of the Mature and Aging Thymus
Noradrenergic Innervation of the Mature and Aging Spleen
ß-Adrenergic Receptors on Cells of the Immune System with Age
Significance of Age-Related Alterations in Noradrenergic Sympathetic Innervation of Lymphoid Organs: Possible Relationship to an Age-Related Decline in Immune Function
Summary
References
Neocortex Lateralization of Immune Function and of the Activities of Imuthiol, a T-Cell Specific Immunopotentiator
Introduction
Lateralized Influence of Neocortex on Immune Function
Immunoenhancing Effects of Imuthiol Are under Lateralized Neocortical Control
Conclusions
References
T-Lymphocyte Entry and Antigen Recognition in the Central Nervous System
Introduction
T-Lymphocyte Entry into the Central Nervous System
Antigen Presentation in the Central Nervous System
Summary
References
Interaction of the Mucosal Immune and Peripheral Nervous Systems
Introduction
Mucosal Architecture
Innervation of Immune Cells in Mucosal Sites
Nerve Growth Factor
Intersystem Communication
Possible Mucosal Neuroimmunological Pathways
Conclusions
References
Immunologic Properties of Substance P
Introduction
Substance P and Human Inflammatory Disorders
Cellular Interactions with Substance P
Substance P Receptors
Conclusions
References
Vasoactive Intestinal Peptide and Immune Function
Introduction
Structure and Biosynthesis
Availability and Distribution
Binding of Vasoactive Intestinal Peptide to Lymphoid Cells
Opportunity of Lymphoid Cells to Bind Vasoactive Intestinal Peptide
Effects of Vasoactive Intestinal Peptide on Lymphoid Cells
Vasoactive Interstinal Peptide
Future Directions
References
Production and Recognition of Neuropeptides by Cells of the Immune System
Introduction
Neuroendocrine Peptides from Immunological Cells
Conversion and Degradation of Neuropeptides by Immune Cells
Neuropeptide Mediation of Immunological Reactions, Inflammation, and Tissue Repair Processes
Human Lymphocyte Receptors for Neuropeptides
Pathogenetic Roles of Neuropeptides in Immune Diseases
Summary
References
Catecholamine Action and Immunologic Reactivity
Introduction
Catecholamines and Lymphocyte Responsiveness in Vitro
Catecholamines and Lymphocyte Activity in Vivo
Discussion: Role of Catecholamines in the Regulation of Immune Reactivity
Conclusions
References
Neurotransmitters and Molecular Signaling in the Immune Response
Introduction
Role of Catecholamines in Modulating Immunity
Modulation of T-Cell Function by Stimulation of ß-Adrenergic Receptors
Molecular Neuroimmunomodulation-Consequences of Dual Receptor Signaling
Concluding Remarks
References
Part II Neuroendocrine-Immune System Interactions
Effects of Hypophysectomy on Immune Function
Introduction
The Pituitary Gland
Methods of Hypophysectomy and Pituitary Grafting
Hypophysectomy, Hemopoiesis, and Immunity
Discussion
Summary
References
Growth Hormone in Immunobiology
Introduction
A Look at the Past
Growth Hormone Deficiency
Growth Hormone, Thymic Involution, and Aging
Growth Hormone and Lymphocytes
Growth Hormone and Hemopoiesis
Growth Hormone and Phagocytic Cells
Growth Hormone in the Immune Response
A Look to the Future
References
Prolactin and Immune Function
Introduction
Physiological and Pharmacological Regulation of Prolactin Secretion
Effects of Prolactin on Immune Function
Cellular Effects of Prolactin in Immune Tissues
Questions for Future Research
Summary
References
Corticotropin-Releasing Hormone and Proopiomelanocortin-Derived Peptides in the Modulation of Immune Function
Introduction
Induction of Proopiomelanocortin-Derived Peptides by Corticotropin-Releasing Hormone
Influence of Proopiomelanocortin-Derived Peptides on Immune Function
Epilogue
References
Glucocorticoids and Immune Function
Introduction
Molecular Mechanisms of Glucocorticoid Actions
Glucocorticoid Modulation of Mediators of Immune and Inflammatory Reactions
Glucocorticoid Effects on Mononuclear Phagocytes
References
Sex Hormones and Immune Function
Introduction
Male/Female Differences in Immunity
Effect of Sex Steroids on the Immune System
References
Role of the Pineal Neurohormone Melatonin in the Psycho-Neuroendocri…
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